|
Immunologic Deficiency Syndromes
|
0.450 |
GeneticVariation
|
group |
BEFREE |
Mutations in the DNMT3B DNA methyltransferase gene cause the ICF immunodeficiency syndrome.
|
12900541 |
2002 |
|
Immunologic Deficiency Syndromes
|
0.450 |
GeneticVariation
|
group |
BEFREE |
Mutation in the DNMT3B DNA methyltransferase gene is a common cause of ICF (immunodeficiency, centromeric heterochromatin, facial anomalies) immunodeficiency syndrome and leads to hypomethylation of satellites 2 and 3 in pericentric heterochromatin.
|
11702227 |
2001 |
|
Immunologic Deficiency Syndromes
|
0.450 |
Biomarker
|
group |
BEFREE |
Chromosomal abnormalities associated with hypomethylation of classical satellite regions are characteristic for the ICF immunodeficiency syndrome.
|
11063717 |
2000 |
|
Immunologic Deficiency Syndromes
|
0.450 |
GeneticVariation
|
group |
BEFREE |
Lsh/HELLS is critical for normal development and mutations of Lsh in human cause the ICF (Immune deficiency, Centromeric instability, Facial anomalies) syndrome, a severe immune disorder with multiple organ deficiencies.
|
30861354 |
2019 |
|
Immunologic Deficiency Syndromes
|
0.450 |
Biomarker
|
group |
CTD_human |
Hematopoietic stem cell transplantation corrects the immunologic abnormalities associated with immunodeficiency-centromeric instability-facial dysmorphism syndrome.
|
17908720 |
2007 |
|
Immunologic Deficiency Syndromes
|
0.450 |
GeneticVariation
|
group |
BEFREE |
The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome.
|
10588719 |
1999 |
|
Immunologic Deficiency Syndromes
|
0.450 |
Biomarker
|
group |
HPO |
|
|
|
|
Mammary Neoplasms
|
0.340 |
Biomarker
|
group |
CTD_human |
DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines.
|
18221536 |
2008 |
|
Mammary Neoplasms
|
0.340 |
AlteredExpression
|
group |
LHGDN |
DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines.
|
18221536 |
2008 |
|
Mammary Neoplasms
|
0.340 |
Biomarker
|
group |
CTD_human |
Clinicopathologic significance of DNA methyltransferase 1, 3a, and 3b overexpression in Tunisian breast cancers.
|
22520950 |
2012 |
|
Mammary Neoplasms
|
0.340 |
AlteredExpression
|
group |
BEFREE |
We suggest that these altered CTCF and DNMT3b expression patterns represent (a) critical events responsible for the epigenetic inactivation of BRCA1 and (b) a diagnostic signature for epigenetic inactivation of other tumour suppressor genes in sporadic breast tumours.
|
17071074 |
2007 |
|
Mammary Neoplasms
|
0.340 |
AlteredExpression
|
group |
BEFREE |
Although we failed to identify underexpression of specific target genes associated with DNMT increasing expression, the frequent overexpression of DNMT3B in this breast tumor series points to DNMT3B as a potential new therapeutic target in breast cancer.
|
14555514 |
2003 |
|
Mammary Neoplasms
|
0.340 |
Biomarker
|
group |
BEFREE |
Our results indicated that DNMT3A and DNMT3B promoters were demethylated in breast tumors as compared to control tissues.
|
29574992 |
2018 |
|
Mammary Neoplasms
|
0.340 |
AlteredExpression
|
group |
LHGDN |
Although we failed to identify underexpression of specific target genes associated with DNMT increasing expression, the frequent overexpression of DNMT3B in this breast tumor series points to DNMT3B as a potential new therapeutic target in breast cancer.
|
14555514 |
2003 |
|
Prostatic Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Polymorphisms in the DNA methyltransferase 3b gene and prostate cancer risk.
|
16012746 |
2005 |
|
Prostatic Neoplasms
|
0.310 |
GeneticVariation
|
group |
LHGDN |
Polymorphisms in the DNA methyltransferase 3b gene and prostate cancer risk.
|
16012746 |
2005 |
|
Stomach Neoplasms
|
0.310 |
AlteredExpression
|
group |
LHGDN |
The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer.
|
18253830 |
2008 |
|
Stomach Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer.
|
21458988 |
2011 |
|
Mood Disorders
|
0.310 |
Biomarker
|
group |
PSYGENET |
Thus, our data suggest that the altered expression of DNMTs is state dependent and that the aberrant epigenetic gene regulations caused by the altered expression of DNMT1 and DNMT3B may be associated with the pathophysiology of mood disorders.
|
21592522 |
2011 |
|
Mood Disorders
|
0.310 |
AlteredExpression
|
group |
BEFREE |
Thus, our data suggest that the altered expression of DNMTs is state dependent and that the aberrant epigenetic gene regulations caused by the altered expression of DNMT1 and DNMT3B may be associated with the pathophysiology of mood disorders.
|
21592522 |
2011 |
|
Carcinoma
|
0.300 |
Biomarker
|
group |
CTD_human |
High DNMT1 and DNMT3b expression was found in 105/127 (83%) and 79/127 (62%) carcinomas, respectively.
|
21458988 |
2011 |
|
Craniofacial Abnormalities
|
0.300 |
Biomarker
|
group |
CTD_human |
Hematopoietic stem cell transplantation corrects the immunologic abnormalities associated with immunodeficiency-centromeric instability-facial dysmorphism syndrome.
|
17908720 |
2007 |
|
Liver neoplasms
|
0.210 |
Biomarker
|
group |
RGD |
Immunoblot assay showed that the levels of DNMT1, DNMT3a, and DNMT3b proteins in the hepatoma were 5-, 10-, and 4-fold higher, respectively, than in the liver.
|
11844796 |
2002 |
|
Liver neoplasms
|
0.210 |
AlteredExpression
|
group |
BEFREE |
DNMT3b may play an important role in regulation of FHIT expression in hepatoma SMMC-7721 cells, but not through methylation of the FHIT promoter.
|
19502167 |
2009 |
|
Anxiety Disorders
|
0.200 |
Biomarker
|
group |
RGD |
Gestational hypoxia induces sex-differential methylation of Crhr1 linked to anxiety-like behavior.
|
23529784 |
2013 |